Los Angeles: Actress Reese Witherspoon is in talks to star in the indie comedy film “Home Again”. Hallie Meyers-Shyer, the daughter of director Nancy Meyers, is writing and directing the film, reports variety.com. Meyers is producing the film alongside Erika Olde, who is also financing the movie. Nancy Meyers played a major part in getting the script in Witherspoon's hands. Based on a script by Meyers-Shyer, “Home Again” follows a recently separated mother of two whose new life in Los Angeles is overturned when she decides to take in three young, charismatic guys. Witherspoon has recently focused on producing more material for herself like the upcoming HBO limited series “Big Little Lies”, which also stars actress Nicole Kidman and is expected to be released next year on HBO.